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The DMN cannot only be assessed as a pattern of task-induced deactivation but can also be derived from the intrinsic resting-state BOLD signal intensity of the brain by means of resting-state connectivity analyses. When we applied 2 main approaches, VOI-based correlation analyses and whole-brain-based ICA to resting-state data of healthy controls, subjects with MCI, and patients with AD we found that time-course correlation analyses seem to outperform independent-component analyses in the identification of patients with AD ( Giuseppe Zanotti Suede ThighHigh Boots Sale Cheapest Price Original For Sale Discount Manchester Buy Cheap Professional TekFL
). 81 A study by Wang et al 82 choosing the bilateral hippocampus as a VOI found disrupted connectivity predominantly between the right hippocampus and the main components of the DMN in AD. 82

Fig 2.

DMN connectivity of the ACC/medial prefrontal cortex and the PCC in healthy elderly subjects, those with MCI, and those with AD. A recent study by Koch et al demonstrated high classification accuracy by using multivariate analysis approaches.

fMRI studies in MCI have revealed altered cerebral activation in subjects with MCI during visual-processing 83 and working-memory tasks. 84 In subjects with MCI, medial temporal activation during memory tasks was shown to be increased, in contrast to reduced activation consistently observed in mild AD. 84 However, according to Celone et al, 76 this seemingly paradoxic hyperactivation of the hippocampus during memory tasks predominantly occurs in early stages of MCI, whereas more impaired MCI subjects revealed significantly decreased activation levels, similar to those in patients with AD. This increased medial temporal activation may be characteristic of a compensatory phase in subjects with early MCI, preceding the phase of decreased activation in the same regions with the transition from MCI to mild AD. 85

Task-dependent functional connectivity among the medial temporal lobe, the PCC, and the parietal lobe has also been shown to be decreased in MCI, suggesting a disruption of connections between these memory and DMN regions by the characteristic early accumulation of AD-type neuropathology in these areas. 86

Task-independent functional connectivity, as assessed by resting-state MR imaging, has likewise revealed reduced network connectivity between selected areas of the DMN and the executive attention network. In a study by Sorg et al., 87 functional connectivity between both hippocampi and the PCC of the DMN was present in controls but was not detectable in subjects with MCI. This functional-connectivity alteration was shown to be accompanied by decreased medial temporal lobe volumes as assessed by VBM. 87

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Ralf Oettmeier

Stellar Biomolecular Research (SBR) and FCTI Germany

Title: The procaine-(base)-infusion: A review after twenty years of use

Ralf Oettmeier had his medical studying at the Friedrich-Schiller-University Jena (Germany). From 1993 – 2014 he worked in his own outpatient department with the focus on reflex therapies (Chirotherapy, Acupuncture, Neural Therapy), Homeopathy and special pain treatment and as leading head physician in the Clinic „ im LEBEN “ at Greiz, Germany. Since 2014 he is leading Doctor at the Paracelsus Clinic Lustmühle, Switzerland, a Comprehensive Center for Biologic-Integrative Medicine and Dentistry. He realizes considerable activities of seminars and presentations in the fields of Biological Medicine, is author of textbooks and publications in CAM, and finally of some guidebooks for patients.

Since its creation in 1905, Procaine (or Novocain) has been used in different ways, by several authors with therapeutic aims. Within these authors is important to mention to Vishnevsky, Leriche, Speransky, Huneke and Aslan . However, the highly-dosed infusion of Procaine-HCl with sodium bicarbonate as additive was first published twenty years ago. The method advanced to a routine therapy in many centers for pain treatment, rehabilitation and natural medicine.

The aim of this procedure is the systemic use of the various pharmacological features of Procaine, especially to inhibit pain and inflammation, for vasodilatation, anti-oxidation and to harmonize the nervous system.Beside the routine application of 2-3 ml pure procaine (1%) meanwhile the high-dosed procaine (base) infusionadvanced to a routine in many centers for pain treatment, rehabilitation and natural medicine, especially in the German-speaking countries. On one hand shall the addition of sodium-bicarbonate balance the common latent pH-decrease in the periphery on the other hand also the degradation products of Procaine (DAE and PABA) have a systemic effect. For the safety of the patients and to improve the success rate of the method it was shown that the classic Procaine-Base-infusion should be only realized on the base of a prior acid-base-diagnostic. We recommend to start with a dosage of 100 mg Procain-HCl and 20 ml sodium-hydrogen-carbonate (8,4%) in 250 till 500 ml basic solution.The infusion takes place over approximately 45 – 60 Minutes. In steps of additionally 50 mg Procain-HCl and 10 ml sodium-bicarbonate (8,4%) the Procaine-Base infusion will be titrated till to the appearance of a good action.In patients with cardiovascular risk factors we recommend the use of surveillance technique (EKG, oximetry) up to 250 mg Procain-HCl. It is advised to ensure an after-treatment observation of 30 Minutes.Without any acid-base-household diagnostics before the Procaine-Base-infusion should not be administered more often than three times weekly and should have at minimum one day distance between. A series of 6 till 10 infusions depending from the problem have been approved.After meanwhile over 400.000 application of infusion neural therapy according the described regime in our clinic and outpatient department we have not observed one case with long-term or severe side effects. Indications ofProcaine-(Base)-Infusion: The multiple Procaine features in combination with the alkaline additive are responsible for the enormous palette of medical indications. Especially all kinds of pain, inflammatory and auto-immune diseases, vegetative dysbalances and the complementary cancer medicine are standing in the foreground. Acute situations :Radicular syndrome, Pseudo-radicular syndrome, acute infection,early stage of Algodystrophia, sudden deafness, inflammations,migraine, activated osteoarthritis,postoperative paintreatment, followings of injuries. Chronic pain : multiple Arthralgia, chronic Radicular-/Pseudo-radicular syndrome,Algodystrophia, all kinds of Neuralgia, facetted pain syndrome, pain in patients with reduced kidney function. Chronic I nflammations: Lupus erythema odes, Rheumatoid-Arthritis, Psoriatic Arthritis,Scleroderma, Neurodermitis, Multiple Sclerosis, Mb. Crohn, Colitisulcerous, Nephritis, patients after Kidney Transplantation. Others :periphery circulatory disorders, constipation, Dysmenorrhea clinical and Para-clinical hints for tissue acidosis, osteoporosis complementary cancer therapy, pre- and post-operative .

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  • Matteo Gianpietro Zago

    Medium member since Dec 2017

    Guinness World Record by creating the Most commented Item in the Web 2.0 history. Chairman @ The Internet of Blockchains Foundation. Founder @ Essentia.one.