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Li, Tzu-Hao; Liu, Chih-Wei; Lee, Pei-Chang; Huang, Chia-Chang; Lee, Kuei-Chuan; Hsieh, Yun-Cheng; Yang, Ying-Ying; Hsieh, Shie-Liang; Lin, Han-Chieh; Tsai, Chang-Youh

For steatotic livers , pharmacological approaches to minimize the hepatic neutrophil and macrophage infiltration, and cytokine and chemokine release in ischemia-reperfusion (IR) injury are still limited. Tumor necrosis factor (TNF)-α superfamily-stimulated pathogenic cascades and M1 macrophage/Kupffer cells (KC) polarization from Th1 cytokines are important in the pathogenesis of IR liver injury with hepatic steatosis (HS). Conversely, anti-inflammatory M2 macrophages produce Th2 cytokine (interleukin-4), which reciprocally enhances M2 polarization. Toll-like receptor 4-activated KCs can release proinflammatory mediators, skew M1 polarization and escalate liver IR injury. Decoy receptor 3 (DcR 3 ) could be potential agents simultaneously blocking the IR liver injury-related pathogenic changes and extend the survival of steatotic graft. Rats were fed with methionine and choline-deficient high-fat diet (MCD HFD) for 6 weeks to induce HS. Preliminary experiments with HS group and IR group were conducted, and either immunoglobulin G Fc protein or DcR3 analogue was treated for 14Âdays in all groups to evaluate the severity. In the Zucker rat -focused experiments, various serum and hepatic substances, M1 polarization, and hepatic microcirculation were assessed. We found that serum/hepatic DcR 3 levels were lower in nonalcoholic fatty liver disease patients with HS. DcR 3 a protected Zucker rats with HS from IR liver injury. The beneficial effects of DcR 3 a supplement were mediated by inhibiting hepatic M1 polarization of KCs, decreasing serum/hepatic TNFα, nitric oxide, nitrotyrosine, soluble TNF-like cytokine 1A, Fas ligand, and interferon-γ levels, neutrophil infiltration, and improving hepatic microcirculatory failure among rats with IR-injured steatotic livers . Additionally, downregulated hepatic TNF-like cytokine 1A/Fas-ligand and toll-like receptor 4/nuclear factor-κB signals were found to mediate the DcR 3 a-related protective effects of steatotic livers from

Counteraction of oxidative damage in the rat liver by an ancient grain (Kamut brand khorasan wheat).

Benedetti, Serena; Primiterra, Mariangela; Tagliamonte, Maria Chiara; Carnevali, Andrea; Gianotti, Andrea; Bordoni, Alessandra; Canestrari, Franco

We previously demonstrated in rat plasma the antioxidant protective effect of whole-grain bread, particularly when made from Kamut brand khorasan wheat. In the present study, we investigated the effects of the same experimental breads in rat liver using two different bread-making procedures (baker's yeast and sourdough fermentation). Rats were examined in the basal condition and after the administration of doxorubicin, a pro-oxidative agent. The following parameters were measured in liver homogenates: glutathione peroxidase and thioredoxin reductase activities, as antioxidant enzymes containing selenium; glutathione, α-tocopherol and β-carotene, as major non-enzymatic cell antioxidants; malondialdehyde and advanced oxidation protein products, as markers of oxidative damage to lipids and proteins, respectively. A histologic evaluation of liver tissue was also conducted. In agreement with our previous work, we observed a lower oxidative status and a different activity of glutathione peroxidase and thioredoxin reductase in rats fed the whole-grain Kamut khorasan bread than in rats fed the modern whole-grain durum wheat bread. Histologic evaluation of the hepatic tissue showed the onset of inflammation in response to doxorubicin only in rats fed the modern durum wheat bread. Our data confirm that bread made from whole-grain Kamut khorasan protects rats from oxidative stress better than bread made from whole-grain durum wheat. This is consistent with their different antioxidant profiles. The type of wheat used for bread-making appeared to be the main determinant of the observed protective effect. Copyright © 2012 Elsevier Inc. All rights reserved.

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Noah Baumbach, left. (Photo: Daniel Maurer)

Have you seen the Noah Baumbach movie about the sons grappling with their father’s divorce and hislegacy as an artistic has-been?No, I’m not talking about The Squid and the Whale . I’m talking about Baumbach’s latest movie about this, The Meyerowitz Stories (New and Selected) , which will have itsNorth American premiereat the New York Film Festival on Monday and comes to Netflix Oct. 13.

As the title indicates, Meyerowitz is about a completely different family, but Baumbach admits that he “kind of went back to The Squid and the Whale ” for this dramedy. “I had started [ The Squid and the Whale ] writing from an adult perspective and then scrapped it to go back and write from the child’s perspective,” he explained during a press conference at Lincoln Center.

In Meyerowitz , the siblings are full-grown adults, complete with hip problems and divorces of their own, but they’re still grappling with the egoism of their emotionally distant father, Harold (Dustin Hoffman), a sculptor who once got a piece in the Whitney but never hit it big. He lives near Astor Place, in a townhouse any New Yorker would envy, but he resentspeers like the old friend (Judd Hirsch) who’s now selling paintings to Sigourney Weaver (the actress makes an appearance, as does Candice Bergen).

But back to the kids: Danny (Adam Sandler) is a loving dad to his daughter (Grace Van Patten) but this fails to impress his father, who doesn’t understand why Dannyever quit the piano. Matthew (Ben Stiller) is a wealth manager to celebrity clients like thenouveau-richemusician/coffee roaster who wants to put a swimming pool into the building he just bought in Greenpoint(Adam Driver, who previously starred alongside Stiller in Baumbach’s While We’re Young ). Thiscareer choice also fails to impress Harold, who believes, in Baumbach’s words, that “art is religion,” and wants his favorite son to follow in his footsteps.Finally,Jean (Elizabeth Marvel) is a shrinking violet who is all but invisible to the family patriarch– and, for that matter, to her brothers.

As if channeling Faulkner’s The Sound and the Fury via Wes Anderson, the filmdedicates separate chapters to each sibling. Baumbachsaid the structure followed that of a short story collection—hence (New and Selected) . “I was thinking of authors who’ve returned to the same family over time,” he said, citing John Updike’s The Maple Stories , a collection of fiction written over the course of four decades.

“I found something extra moving about the fact that these stories existed in real time and weren’t preordained,” Baumbach said. “There was something very sad to me that [Updike] arrived at these conclusions for these people that he didn’t necessarily have when he published the first story years before.”

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The LG V30 (pictured) already has a dual rear-facing camera system, but the company’s next phone may have even more cameras.
Photo illustration by Slate. Photo by LG.

The camera is one of a smartphone’s most important features. In 2017, analysts with Keypoint Intelligence estimated that we’d collectively snap more than 1.2 trillion photos over the course of the year (and that stat doesn’t include the number of videos we’d record). Naturally, smartphone-makers are using this tendency to their advantage. One strategy they’re using: increasing the number of cameras on the device.

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The trend of multiple rear-facing cameras is interesting, however, and not just for the more detailed imagery and broader photographic scope these systems enable. This type of advanced smartphone camera wasn’t feasible a few years ago, at least not with the ease that’s available today. Thanks to advances in machine learning and artificial intelligence, smartphone camera software can quickly and intelligently optimize photograph settings based on the conditions you’re shooting in, whether that be low light, a wide, distant scene, or an up-close portrait of a single person. The phone is able to utilize both cameras as needed, without requiring its owner to fiddle with different modes or intricate camera settings menus. That’s not to say that these phones don’t offer such settings: The iPhone’s Cheap Many Kinds Of Ulla Johnson Suede WrapAround Boots Free Shipping Real Latest Online Fashion Style High Quality Online 88mpM
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